THIQ = Tetrahydroisoquinoline

For many years, the medical community has been doing expansive research on the biological complexities of the Alcoholic. But, perhaps, one of the most intriguing discoveries was made quite by accident.

It all started down in Houston, Texas with a medical scientist named Virginia Davis who was busy doing cancer research. For her studies, Virginia needed access to fresh human brains, which, as we know, are not readily available. Virginia would ride along with the Houston police on their early morning rounds as they patrolled skid row, collecting the bodies of the street alcoholics who died overnight. After taking the temperatures of the bodies, Virginia would rush the warm ones back to the hospital where she could remove their brains for her cancer research.

One day, Virginia was in the hospital cafeteria talking to her colleagues. She began telling them about some of the findings of her laboratory studies, and she said: "You know I never realized that all those winos used heroin as well as booze." These were seasoned emergency room doctors; they just laughed at her. "Come on Virginia," they told her. "These guys don't use heroin. They can barely afford a bottle of cheap muscatel."

Virginia knew she was onto something. She had discovered in the brains of those chronic alcoholics a substance that is very closely related to heroin. This substance is called, Tetrahydroisoquinoline or THIQ for short. When a person uses heroin, the heroin breaks down in the system and one of the by-products is THIQ. Virginia's mystery was; how did this THIQ get into the brains of these hardcore alcoholics?

To better understand all of this, we will need a small lesson in biochemistry. When the normal adult drinker takes in alcohol it's processed at about one drink per hour. The body first converts the alcohol into something called acetaldehyde (a very toxic substance that if accumulated would make one very sick or could be fatal). The body is designed, via biological processes, to quickly rid itself of this toxic acetaldehyde. It is changed into acetic acid (vinegar), and then into carbon dioxide and water, which is dispelled through the kidneys and lungs. That's what happens in a "normal" drinker. It also happens with the alcoholic drinker, but there is a "P.S.".

As was discovered by Virginia Davis, in the alcoholic, a very small amount of acetaldehyde is not eliminated. Instead, it goes to the brain where, through a very complex biochemical process, it is transformed into THIQ. Here is a little information about THIQ.

First, THIQ is created in the brain, and it only occurs in the brain of the alcoholic drinker; it does not and cannot happen in the brain of the social drinker. Second, THIQ has been found to be highly addictive. It was used experimentally with animals during WWII when doctors were looking for a pain killer less addictive than morphine. THIQ turned out to be an excellent pain killer but its addictive qualities far exceed that of morphine. The third fascinating item about THIQ also has to do with addiction. An experiment using alcohol averting rats and THIQ was conducted. These rats, when put into a cage with a very weak solution of vodka and water, will refuse to drink it to the point where they will thirst to death. Take the same rat and inject a minute quantity of THIQ into its brain and the animal will immediately develop an intense preference for alcohol over water. So, with one small injection of THIQ, the rat bred to refuse alcohol, had become an alcoholic rat.

Other studies have been done with monkeys, a very- close relative to humans in medical terms. What has been learned is that once THIQ is injected into. a. monkey's brain, it stays there. You can keep a THIQed monkey dry, off alcohol, for as long as seven years and when the monkey is sacrificed and his brain is examined, the THIQ is still there.

For a long time, specialists in the alcoholism field have suspected what these laboratory findings verified. Specialists have noticed, for- years, that through the exploration of an alcoholic's family history, there is inevitably. evidence of alcoholism within said family. In virtually all cases of alcoholism, there -is a family predisposition - an abnormality in the body chemistry - toward the manufacturing of THIQ.

We know alcoholics don't intend to make THIQ when they start. drinking and become addicted to alcohol. They don't mean for their brains to manufacture something stronger than morphine. They've been warned about the evils of narcotics but they've heard a great deal less about the power and potential of alcohol. Most people take a drink now and then and according to a study done by the National Institute on Drug Abuse, 92% of high school seniors have had experiences with alcohol & 67% are current users (1987). Within our society alcohol consumption is not just accepted behavior, it is expected.

Unfortunately, the alcoholics-to-be aren't equipped to process alcohol in the normal way. They are unaware of their predisposition toward the THIQ production their brain's chemistry has inherited. Most people didn't know anything about this condition until fairly recently. So the alcoholics-to-be innocently start drinking moderately in the beginning, maybe a few drinks on the weekends. As their drinking progresses, they might get seriously drunk two or three times a year. No real life problems seem to have developed. During all these drinking episodes, the brain is busy making a little cache of THIQ. At some point, maybe sooner or later, the alcoholic will cross over that shadowy line into a whole new alcoholic way of life.

Medical science still cannot predict with accuracy how much THIQ an individual brain will stockpile before the "big event" happens. Some people cross the line in their teens, others, in their 30's, 40's, 50's or later. But once it happens, the alcoholic will be as hooked on alcohol as he would have been hooked on heroin if he'd been shooting that up instead for very similar chemical reasons.

As dismal as this picture may appear, there is good news. Alcoholism is a disease and is arrestable and highly treatable. Alcoholism is neither the alcoholics fault nor his choice. Today alcoholics can get proper treatment for their disease, and that treatment begins when the alcoholic patient begins to get the facts on their disease.

These facts, when properly presented, can begin to alleviate some of the massive guilt that consumes the alcoholic. Treatment can begin to replace the guilt with a sense of the need for the alcoholic to become responsible for himself and accountable for his/her actions. Through quality treatment with knowledgable caring professionals, the alcoholic can put himself /herself on the path of recovery. With the help of others and a strong support system he/she can live a healthy fruitful life. That's the good news for all of us. For the alcoholics and their significant others, it's the best news they can ever wish for.

Andrew Eisenhauer -- (This article was based on the writings of Dr. David L. Ohlms from his book: "The Disease Concept of Alcoholism").

More easy to ready science...I'm researching the nutrients that clear the THIQ components such as acetylaldehyde..

T.H.I.Q. --Biochemical Culprit
Heredity studies, done all over the world, clearly show that genetics is far more significant in determining whether or not you'll be an alcoholic than any other single factor. Genetics is more significant than any combination of social or environmental factors examined.

The report is not saying that a person is born an alcoholic. However, evidence is conclusive that some people are indeed at greater risks to alcoholism because of their heredity, and if they ever start drinking they run a high risk of developing the disease.

If you love your children don't condemn them with a high chance of getting this disease, stop your drinking!

T.H.I.Q. was discovered in brains of alcoholics in Houston, Texas by a scientist named Virginia Davis who was doing cancer research. For her study she needed fresh human brains and used bodies of homeless winos who had died during the night and were picked up by Houston police in the morning.

She discovered in the brains of those chronic alcoholics a substance that is closely related to Heroin. This substance, known to scientists, is called Tetrahydrolsoqulnoline or THIQ When a person shoots heroin into their body, some of it breaks down and turns into THIQ The Alcoholics studied had not been using heroin so how did the THIQ get there?

When the normal adult drinker takes in alcohol, it is very rapidly eliminated at the rate of about one drink per hour. The body first converts the alcohol into something called Acetaldehyde. This chemical is VERY TOXIC and if it were to build up inside us, we would get VIOLENTLY SICK AND COULD DIE. But Mother Nature helps us to get rid of acetaldehyde very quickly. She efficiently changes it a couple of more times - into carbon dioxide and water - which is eliminated through kidneys and lungs. That's what happens to normal drinkers. It also happens with alcoholic drinkers, but with alcoholic drinkers something additional happens.

What Virginia discovered in Houston has been extensively confirmed since. In alcoholic drinkers, a very small amount of poisonous acetaldehyde is not eliminated. Instead it goes to the brain. There through a very complicated biochemical process, it winds up as THIQ

Research has found the following:

THIQ is manufactured in the brain and only occurs in the brain of the alcoholic drinker. It is not manufactured in the brain of the normal social drinker of alcohol.

THIQ has been found to be highly addictive. It was tried in experimental use with animals during the Second World War when we were looking for a painkiller less addicting than morphine. THIQ was a pretty good pain killer but t couldn't be used on humans. It turned out to be much more addicting than morphine.

Experiments have shown that certain kinds of rats cannot be made to drink alcohol. Put in a cage with very weak solution of vodka and water., these rats refuse to touch it. They will literally thirst to death before the agree to drink alcohol. However, if you take the same kind of rat and put a minute quantity of THIQ into the rat's brain -- one quick injection -- the animal will immediately develope a preference for alcohol over water.

Studies done with monkeys, our close animal relative in medical terms, show the following:

Once the THIQ is injected into a monkey's brain, it stays there.

You can keep the monkey dry off alcohol for 7 years but brain studies show that THIQ remains in place in the brain.

The alcoholic's body, like normal drinkers, changes the alcohol into acetaldehyde and then it changes most of it into carbon dioxide and water, which in the end kicks out through the kidneys and lungs. However, the alcoholic's bodies won't kick all these chemicals out. The Alcoholic's brain holds a few bits back and transforms them into THIQ. As THIQ is accumulated in the brain of an alhoholic, at some point, maybe sooner, maybe later, the alcoholic will cross over a shadowy line into a whole new way of living.

It is not known by medical science, at this time, where this line is or how much THIQ an individual brain will pile up before one crosses this line. Some predisposed people cross the line while they're teenagers, or earlier. Others cross in their 30's or 40's and others after retirement. But once this happens the alcoholic will be as hooked on alcohol, as he would have been hooked on heroin if he'd been shooting that instead.

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